Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity.

  title={Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity.},
  author={Bohua Li and Shu Ya Shi and Weizhu Qian and Lei Zhao and Dapeng Zhang and S. -W. Hou and Lei Zheng and Jianxin Dai and Jian Zhao and Hao Wang and Y. -K. Guo},
  journal={Cancer research},
  volume={68 7},
Despite the effectiveness of the anti-CD20 monoclonal antibody (mAb) Rituximab (C2B8) in the treatment of B-cell lymphoma, its efficacy remains variable and often modest. It seems likely that a combination of multiple mechanisms, such as complement-dependent cytotoxicity (CDC) and apoptotic signaling, underlies the therapeutic success of anti-CD20 mAbs. Unfortunately, all the current anti-CD20 mAbs effective in CDC are relatively inactive in signaling cell death and vice versa. In this study… CONTINUE READING


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