Development of novel cell surface CD34-targeted recombinant adenoassociated virus vectors for gene therapy.

@article{Yang1998DevelopmentON,
  title={Development of novel cell surface CD34-targeted recombinant adenoassociated virus vectors for gene therapy.},
  author={Qin Yang and M Mamounas and Gang Yu and Scot Kennedy and Brian Leaker and James Merson and Flossie Wong-Staal and Meijuan Yu and Jack R. Barber},
  journal={Human gene therapy},
  year={1998},
  volume={9 13},
  pages={1929-37}
}
Recombinant adenoassociated virus (rAAV) type 2 vectors have been used to transduce a wide variety of cell types, including hematopoietic progenitor cells. For in vivo gene transfer, it is desirable to have an rAAV vector that specifically transduces selected target cells. As a first step toward generating an rAAV vector capable of targeting delivery in vivo, we have engineered a chimeric protein combining the AAV capsid protein and the variable region of a single-chain antibody against human… CONTINUE READING

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