Development of novel antivirals against flaviviruses.

  title={Development of novel antivirals against flaviviruses.},
  author={Chinmay G Patkar and Richard J. Kuhn},
  journal={Novartis Foundation symposium},
  pages={41-52; discussion 52-6, 71-3, 251-3}
Dengue virus is responsible for a significant amount of human disease in predominantly tropical areas of the world. Much effort has focused on the development of vaccines against the four serotypes of dengue, and within the next few years a vaccine is anticipated. Less progress has been made at developing antivirals that might reduce disease severity. Recent advances in the structural biology of dengue virus and other flaviviruses have opened new possibilities for the rational design of small… CONTINUE READING