Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships.

@article{Koide2002DevelopmentON,
  title={Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships.},
  author={Yuuki Koide and Takeshi Hasegawa and Atsuo Takahashi and Akira Endo and Naoki Mochizuki and Masako Nakagawa and Atsushi Nishida},
  journal={Journal of medicinal chemistry},
  year={2002},
  volume={45 21},
  pages={4629-38}
}
Sphingosine-1-phosphate (S1P) is an intracellular second messenger and an extracellular mediator through endothelial differentiation gene (EDG) receptors, which are a novel class of G-protein-coupled receptors. Although EDG has attracted much attention because of its various roles, no selective agonists or antagonists have yet been developed. This could account for the delay in clarifying the physiological roles of members of the EDG family. Because precise structural information on EDG… CONTINUE READING
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