Development of nonionic contrast media.

  title={Development of nonionic contrast media.},
  author={Torsten H Alm{\'e}n},
  journal={Investigative radiology},
  volume={20 1 Suppl},
In this brief history, the author reviews the observations that led to his developing a nonionic contrast medium. Current knowledge suggested that if a water-soluble medium could be made isotonic to human plasma, it would cause less pain and toxicity than the ionic media then in use. The principles and design of such a medium are discussed, as well as the subsequent chemical development and testing in animal models of first generation (metrizamide) and second generation (iohexol) nonionic media… CONTINUE READING

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