Development of noninvasive fetal DNA diagnosis from nucleated erythrocytes circulating in maternal blood.

@article{Sekizawa2007DevelopmentON,
  title={Development of noninvasive fetal DNA diagnosis from nucleated erythrocytes circulating in maternal blood.},
  author={Akihiko Sekizawa and Yuditiya Purwosunu and Antonio Farina and Takashi Okai and Haruo Takabayashi and Mikiko Kita and Hirofumi Yura and Michihiro Kitagawa},
  journal={Prenatal diagnosis},
  year={2007},
  volume={27 9},
  pages={846-8}
}
BACKGROUND A considerable effort is being spent in developing noninvasive prenatal DNA diagnostic procedures. We recently reported that nucleated erythrocytes (NRBCs) can be enriched from maternal blood by a galactose-specific lectin method. In the present study, to prove that fetal NRBCs are definitely present in maternal blood and are a good source for fetal genetic diagnosis, we evaluated methods for lectin enrichment and subsequent fluorescence in situ hybridization (FISH) analysis through… CONTINUE READING