Development of nitrate tolerance in human arteries and veins: comparison of nitroglycerin and SPM 5185.

@article{Arnet1995DevelopmentON,
  title={Development of nitrate tolerance in human arteries and veins: comparison of nitroglycerin and SPM 5185.},
  author={U A Arnet and Z. H. Yang and Rudolf Siebenmann and Ludvig K von Segesser and Marko Turina and Peter Stulz and Thomas Felix L{\"u}scher},
  journal={Journal of cardiovascular pharmacology},
  year={1995},
  volume={26 3},
  pages={401-6}
}
Nitrate tolerance is a clinical problem in patients with coronary artery disease and heart failure. Human internal mammary arteries and saphenous veins obtained intraoperatively were suspended in organ chambers, and isometric tension was measured. In the artery, nitroglycerin elicited a potent relaxation, which was significantly diminished after prolonged incubation with nitroglycerin (10(-6) M, 1 h). In contrast, no tolerance occurred in saphenous vein under the same conditions. However… CONTINUE READING
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