Development of new vaccines and drugs for TB: limitations and potential strategic errors.

@article{Orme2011DevelopmentON,
  title={Development of new vaccines and drugs for TB: limitations and potential strategic errors.},
  author={Ian M. Orme},
  journal={Future microbiology},
  year={2011},
  volume={6 2},
  pages={161-77}
}
The concomitant HIV and TB epidemics pose an enormous threat to humanity. After invading the host Mycobacterium tuberculosis initially behaves as an intracellular pathogen, which elicits the emergence of acquired specific resistance in the form of a T-helper-1 T-cell response, and involves the secretion of a myriad of cytokines and chemokines to drive protective immunity and granuloma formation. However, after that, a second phase of the disease process involves survival of bacilli in an… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…