Development of new agents for the treatment of advanced colorectal cancer.

@article{Lewis2003DevelopmentON,
  title={Development of new agents for the treatment of advanced colorectal cancer.},
  author={Nancy L. Lewis and Neal J. Meropol},
  journal={Clinical colorectal cancer},
  year={2003},
  volume={3 3},
  pages={154-64}
}
During the past decade, there have been several significant advances in the treatment of metastatic colorectal cancer. These include the introduction of the cytotoxic agents capecitabine, irinotecan, and oxaliplatin. Given their diverse mechanisms of action and toxicity profiles, combinations of fluoropyrimidines, irinotecan, and oxaliplatin have proven feasible and have improved patient outcomes compared with 5-fluorouracil alone. Recently, improved understanding of the biology of colorectal… CONTINUE READING