Development of multiple activities of UDP-glucuronyltransferase in human liver.

@article{Leakey1987DevelopmentOM,
  title={Development of multiple activities of UDP-glucuronyltransferase in human liver.},
  author={Jonathan Leakey and Robert M. Hume and Brian Burchell},
  journal={The Biochemical journal},
  year={1987},
  volume={243 3},
  pages={
          859-61
        }
}
UDP-glucuronyltransferase activities towards eight substrates were assayed in samples of foetal, term and adult human liver. Activities towards bilirubin, androsterone, testosterone, 1-naphthol, 4-nitrophenol and 2-aminophenol were present in foetal and term liver samples at less than 14% of adult values, whereas activity towards 5-hydroxytryptamine was present in foetal and term liver at 109 and 121% of adult values respectively. Thus a 'foetal' form of UDP-glucuronyltransferase may exist in… CONTINUE READING

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