Development of multi-epitope vaccines targeting wild-type sequence p53 peptides.

  title={Development of multi-epitope vaccines targeting wild-type sequence p53 peptides.},
  author={Albert B. Deleo and Theresa L Whiteside},
  journal={Expert review of vaccines},
  volume={7 7},
Loss of p53 tumor-suppressor function is the most common abnormality in human cancer, which can result in enhanced presentation to immune cells of wild-type (wt)-sequence peptides from tumor p53 molecules, thus providing the rationale for wt p53 peptide-based cancer vaccines. We review evidence from preclinical murine tumor models and preclinical studies that led to the clinical introduction of wt p53 peptide-based vaccines for cancer immunotherapy. Overall, this review illustrates the complex… CONTINUE READING
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