Development of mucoadhesive patches for buccal administration of ibuprofen.

@article{Perioli2004DevelopmentOM,
  title={Development of mucoadhesive patches for buccal administration of ibuprofen.},
  author={Luana Perioli and Valeria Ambrogi and Fausta Angelici and Maurizio Ricci and Stefano Giovagnoli and Marinella Capuccella and C. R. Rossi},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2004},
  volume={99 1},
  pages={
          73-82
        }
}
A new formulation for topical administration of drugs in the oral cavity has been developed using several film-forming and mucoadhesive polymers. The films have been evaluated in terms of swelling, mucoadhesion and organoleptic characteristics. The best film, containing polyvinylpyrrolidone (PVP) as film-forming polymer and carboxymethylcellulose sodium salt (NaCMC) as mucoadhesive polymer, was loaded with ibuprofen as a model compound and in vitro and in vivo release studies were performed… CONTINUE READING
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