Development of monoclonal antibodies to the malondialdehyde-deoxyguanosine adduct, pyrimidopurinone.

@article{Sevilla1997DevelopmentOM,
  title={Development of monoclonal antibodies to the malondialdehyde-deoxyguanosine adduct, pyrimidopurinone.},
  author={C L Sevilla and Nels H. Mahle and Naomi Eliezer and Adam Uzieblo and Susan O'Hara and Munetaka Nokubo and Richard Miller and Carol A. Rouzer and Lawrence J Marnett},
  journal={Chemical research in toxicology},
  year={1997},
  volume={10 2},
  pages={172-80}
}
Malondialdehyde (MDA), an endogenous product of lipid peroxidation and prostaglandin biosynthesis, is mutagenic in bacterial and mammalian cells and carcinogenic in rats. In order to determine whether MDA-modified bases are formed in nucleic acids in vivo, sensitive immunoassays to detect MDA-DNA and MDA-RNA adducts are being developed in our laboratory. Murine monoclonal antibodies reactive with the MDA-deoxyguanosine adduct 3-beta-D-erythro-pentofuranosylpyrimido[1,2-alpha]purin-10(3H)-one… CONTINUE READING

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