Development of monoclonal antibodies against human CYP11B1 and CYP11B2

  title={Development of monoclonal antibodies against human CYP11B1 and CYP11B2},
  author={Celso Enrique Gomez-Sanchez and Xin Qi and Carolina Velarde-Miranda and Maria W Plonczynski and Elise P Gomez-Sanchez},
  journal={Molecular and Cellular Endocrinology},
1. The final enzymes in the biosynthesis of aldosterone and cortisol are by the cytochrome P450 CYP11B2 and CYP11B1, respectively. The enzymes are 93% homologous at the amino acid level and specific antibodies have been difficult to generate. 2. Mice and rats were immunized with multiple peptides conjugated to various immunogenic proteins and monoclonal antibodies were generated. The only peptide sequences that generated specific antibodies were amino acids 41-52 for the CYP11B2 and amino acids… CONTINUE READING


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