• Biology
  • Published 1988

Development of molecular approaches to the estimation of the germinal gene mutation rate in human populations

@inproceedings{Perry1988DevelopmentOM,
  title={Development of molecular approaches to the estimation of the germinal gene mutation rate in human populations},
  author={B. A. Perry and Harvey W. Mohrenweiser},
  year={1988}
}
In view of this potential for germinal mutations to result in genetic disease, it is important to establish a basis upon which to estimate the rate of occurrence of de novo gene mutations and the impact of mutagenic agents in increasing the frequency of these events. Estimates based upon a variety of approaches place the ''spontaneous/background'' germinal gene mutation rate in humans in the neighborhood of 0.4 /times/ 10/sup -5/ events per locus per generation, or a nucleotide substitution… CONTINUE READING