Development of microextraction by packed sorbent for toxicological analysis of tricyclic antidepressant drugs in human oral fluid.

@article{Woniakiewicz2014DevelopmentOM,
  title={Development of microextraction by packed sorbent for toxicological analysis of tricyclic antidepressant drugs in human oral fluid.},
  author={M. Woźniakiewicz and R. Wietecha-Posłuszny and Agnieszka Moos and M. Wieczorek and P. Knihnicki and P. Kościelniak},
  journal={Journal of chromatography. A},
  year={2014},
  volume={1337},
  pages={
          9-16
        }
}
The aim of this study was to apply microextraction by packed sorbent (MEPS) to the isolation of six tricyclic antidepressants (TCADs): nordoxepin, doxepin, desipramine, nortriptyline, imipramine, and amitriptyline from human oral fluid. Samples were collected from healthy volunteers via free spillage from the oral cavity to disposable test tubes. A method of oral fluid sample pretreatment was developed and optimized in terms of suitability for MEPS extraction and removing of interfering agents… Expand
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