Development of mice expressing a single D-type cyclin.

  title={Development of mice expressing a single D-type cyclin.},
  author={Maria A Ciemerych and Anna Marie Kenney and Ewa T. Sicinska and Ilona Kalaszczynska and Roderick Terry Bronson and David H Rowitch and Humphrey Gardner and Piotr Sicinski},
  journal={Genes & development},
  volume={16 24},
D-cyclins (cyclins D1, D2, and D3) are components of the core cell cycle machinery. To directly test the ability of each D-cyclin to drive development of various lineages, we generated mice expressing only cyclin D1, or only cyclin D2, or only cyclin D3. We found that these "single-cyclin" embryos develop normally until late gestation. Our analyses revealed that in single-cyclin embryos, the tissue-specific expression pattern of D-cyclins was lost. Instead, mutant embryos ubiquitously expressed… CONTINUE READING
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