Development of mammalian nerve-muscle synapses in culture: lack of interference by antibodies to the neural cell adhesion molecule N-CAM and its L2/HNK-1 carbohydrate epitope.

@article{Mehrke1987DevelopmentOM,
  title={Development of mammalian nerve-muscle synapses in culture: lack of interference by antibodies to the neural cell adhesion molecule N-CAM and its L2/HNK-1 carbohydrate epitope.},
  author={G Mehrke and Harald Jockusch and Melitta Schachner},
  journal={Neuroscience letters},
  year={1987},
  volume={78 3},
  pages={247-52}
}
Rat myotubes were cultured with embryonic mouse spinal cord explants. After 4 days of co-culture, (miniature) endplate potentials, (M)EPPs, could be detected in 20-40% of the nerve-contacted myotubes. Polyclonal antibodies against the neural cell adhesion molecule N-CAM and monoclonal antibodies to its L2/HNK-1 carbohydrate epitope were tested for possible effects on synapse formation in this system. Co-cultures that were started and maintained in the presence of Fab fragments of these… CONTINUE READING
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