Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity.

Abstract

In antidiuresis, vasopressin (AVP) occupation of V2 receptors in renal collecting ducts activates adenylyl cyclase, resulting in increased intracellular cAMP levels, which activates protein kinase A (PKA). PKA phosphorylates both the cAMP responsive element binding protein, which induces aquaporin-2 (AQP2) transcription, and AQP2, which then is translocated… (More)

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@article{Li2006DevelopmentOL, title={Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity.}, author={Yuedan Li and Stephen Shaw and Erik-Jan Kamsteeg and Alain Vandewalle and Peter M. T. Deen}, journal={Journal of the American Society of Nephrology : JASN}, year={2006}, volume={17 4}, pages={1063-72} }