Development of lipoprotein(a) siRNAs for mechanism of action studies in non-human primate models of atherosclerosis.


Lipoprotein(a) [Lp(a)] has recently been recognized as an independent risk factor for coronary heart disease. While plasma Lp(a) levels are correlated with cardiovascular risk, the mechanism by which this particle contributes to atherosclerosis is largely unknown. Although humanized transgenic mouse model has recently been described to study Lp(a) biology… (More)
DOI: 10.1007/s12265-014-9605-1



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