Development of light-responsive BNA toward the spatiotemporal control of gene expression.

Abstract

We designed and synthesized light-responsive BNA (bridged nucleic acid), which has a photolabile group at the bridged structure. Light-Responsive BNA can change its structure by a two stages process: photoirradiation followed by nucleophilic treatment. In oligonucleotides containing light-responsive BNA moieties, binding affinity with complementary single-stranded RNA was lost upon photoirradiation, but could be restored by nucleophilic treatment.(1)

DOI: 10.1093/nass/nrp094

Cite this paper

@article{Morihiro2009DevelopmentOL, title={Development of light-responsive BNA toward the spatiotemporal control of gene expression.}, author={Kunihiko Morihiro and Tetsuya Kodama and Masaru Nishida and Takeshi Imanishi and Satoshi Obika}, journal={Nucleic acids symposium series}, year={2009}, volume={53}, pages={187-8} }