Development of isoform-specific sensors of polypeptide GalNAc-transferase activity.

@article{Song2014DevelopmentOI,
  title={Development of isoform-specific sensors of polypeptide GalNAc-transferase activity.},
  author={Lina Song and Collin Bachert and Katrine T-B G Schjoldager and Henrik Clausen and Adam D. Linstedt},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 44},
  pages={30556-66}
}
Humans express up to 20 isoforms of GalNAc-transferase (herein T1-T20) that localize to the Golgi apparatus and initiate O-glycosylation. Regulation of this enzyme family affects a vast array of proteins transiting the secretory pathway and diseases arise upon misregulation of specific isoforms. Surprisingly, molecular probes to monitor GalNAc-transferase… CONTINUE READING