Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways.

@article{Prince2014DevelopmentOI,
  title={Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways.},
  author={Amanda L. Prince and Zachary J. Kraus and Shannon A. Carty and Caleb E Ng and Catherine C. Yin and Martha S Jordan and Pamela L Schwartzberg and Leslie J Berg},
  journal={Journal of immunology},
  year={2014},
  volume={193 2},
  pages={688-99}
}
T cell development in the thymus produces multiple lineages of cells, including innate T cells such as γδ TCR(+) cells, invariant NKT cells, mucosal-associated invariant T cells, and H2-M3-specific cells. Although innate cells are generally a minor subset of thymocytes, in several strains of mice harboring mutations in T cell signaling proteins or transcriptional regulators, conventional CD8(+) T cells develop as innate cells with characteristics of memory T cells. Thus, in Itk-deficient mice… CONTINUE READING
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