Development of inhibitors against TraR quorum-sensing system in Agrobacterium tumefaciens by molecular modeling of the ligand-receptor interaction.

@article{Kim2009DevelopmentOI,
  title={Development of inhibitors against TraR quorum-sensing system in Agrobacterium tumefaciens by molecular modeling of the ligand-receptor interaction.},
  author={Cheoljin Kim and Jaeeun Kim and Hyung-Yeon Park and Hee-Jin Park and Chan Kyung Kim and Jeyong Yoon and Joon-hee Lee},
  journal={Molecules and cells},
  year={2009},
  volume={28 5},
  pages={447-53}
}
The quorum sensing (QS) inhibitors that antagonize TraR, a receptor protein for N-3-oxo-octanoyl-L-homoserine lactones (3-oxo-C8-HSL), a QS signal of Agrobacterium tumefaciens were developed. The structural analogues of 3-oxo-C8-HSL were designed by in silico molecular modeling using SYBYL packages, and synthesized by the solid phase organic synthesis (SPOS) method, where the carboxamide bond of 3-oxo-C8-HSL was replaced with a nicotinamide or a sulfonamide bond to make derivatives of N… CONTINUE READING

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