Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators.

Abstract

Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs, published in vivo studies have generally not been able to demonstrate the expected therapeutically-relevant CB1-mediated effects. Thus, a greater range of molecular tools are required to allow definitive… (More)
DOI: 10.1016/j.bmcl.2016.08.018

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