Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease

  title={Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease},
  author={Paul E. Bendheim and Burkhard Poeggeler and Eyal Neria and Vivi Ziv and Miguel A. Pappolla and Daniel G. Chain},
  journal={Journal of Molecular Neuroscience},
The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer’s disease. Indole-3-propionic acid (IPA, OXIGON™) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying… CONTINUE READING
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2001d) Indole-3propionic acid, a melatonin-related molecule, protects hepatic microsomal membranes from iron-induced oxidative damage: relevance to cancer reduction

  • M. Karbownik, R J.Reiter, +4 authors A. Lewiński
  • J. Cell
  • 2001
2 Excerpts

Alzheimer’s disease: genes, proteins and therapy

  • D J.Selkoe
  • Physiological Reviews
  • 2001

Comparison of the protective effect of melatonin with other antioxidants in the hamster kidney model of estradiol-induced DNA damage

  • M. Karbownik, R J.Reiter, J. Cabrera, J J.Garcia
  • Mutat. Res
  • 2001
2 Excerpts

Targeting small A oligomers : the solution to an Alzheimer ’ s disease conundrum ?

  • L. KleinW., A. KrafftG., E. FinchC.
  • Trends Neurosci .
  • 2001

Targeting small A oligomers: the solution to an Alzheimer’s disease

  • W L.Klein, G A.Krafft, C E.Finch
  • conundrum? Trends Neurosci
  • 2001

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