Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease

@article{Bendheim2002DevelopmentOI,
  title={Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease},
  author={Paul E. Bendheim and Burkhard Poeggeler and Eyal Neria and Vivi Ziv and Miguel A. Pappolla and Daniel G. Chain},
  journal={Journal of Molecular Neuroscience},
  year={2002},
  volume={19},
  pages={213-217}
}
The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer’s disease. Indole-3-propionic acid (IPA, OXIGON™) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying… CONTINUE READING
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