Development of in vitro model systems for destructive joint diseases: novel strategies for establishing inflammatory pannus.


OBJECTIVE To establish a novel 3-dimensional (3-D) in vitro model for the investigation of destructive processes in rheumatoid arthritis (RA). METHODS Two distinct culture systems were developed, consisting of RA synovial membrane and articular cartilage explants or interactive RA synovial cell/chondrocyte cultures embedded in 3-D fibrin matrices. The… (More)


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