Development of improved SNAP25 endopeptidase immuno-assays for botulinum type A and E toxins.

Abstract

Botulinum neurotoxins contain proteases that cleave specific intra-neural proteins essential for neurotransmitter release. Toxin types A, E and C1 intra-cellularly cleave SNAP25 resulting in a flaccid paralysis. As a consequence, various different endopeptidase assays have been developed to specifically detect the toxins enzymatic activity, however, many of… (More)

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Cite this paper

@article{Jones2008DevelopmentOI, title={Development of improved SNAP25 endopeptidase immuno-assays for botulinum type A and E toxins.}, author={Russell G. Jones and Masanari Ochiai and Y Liu and T A N Ekong and Dorothea Sesardic}, journal={Journal of immunological methods}, year={2008}, volume={329 1-2}, pages={92-101} }