Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

@article{Hoos2016DevelopmentOI,
  title={Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations},
  author={Axel Hoos},
  journal={Nature Reviews Drug Discovery},
  year={2016},
  volume={15},
  pages={235-247}
}
  • A. Hoos
  • Published 1 April 2016
  • Biology, Medicine
  • Nature Reviews Drug Discovery
Since the regulatory approval of ipilimumab in 2011, the field of cancer immunotherapy has been experiencing a renaissance. This success is based on progress in both preclinical and clinical science, including the development of new methods of investigation. Immuno-oncology has become a sub-specialty within oncology owing to its unique science and its potential for substantial and long-term clinical benefit. Immunotherapy agents do not directly attack the tumour but instead mobilize the immune… 
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