Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

@article{Sydor2006DevelopmentO1,
  title={Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.},
  author={Jens R Sydor and Emmanuel Normant and Christine S Pien and James R. Porter and Jie Ge and Louis Grenier and Roger H. Pak and Janid A. Ali and Marlene S Dembski and Jebecka A Hudak and Jon S Patterson and Courtney Penders and Melissa Pink and Margaret A. Read and Jim Sang and Caroline N. Woodward and Yilong Zhang and David S Grayzel and Jim Wright and John A. Barrett and Vito J. Palombella and Julian Adams and Jeffrey K. Tong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 46},
  pages={17408-13}
}
Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein homeostasis and the selective chaperoning of key signaling proteins in cancer survival and proliferation pathways has made it an attractive target of small molecule therapeutic intervention. 17-Allylamino-17-demethoxygeldanamycin (17-AAG), the most studied agent directed against Hsp90, suffers from poor physical-chemical properties that limit its clinical potential… CONTINUE READING

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