Development of humanized monoclonal antibody TMA-15 which neutralizes Shiga toxin 2.

Abstract

A murine monoclonal antibody (MAb), VTm1.1, specifically recognizing and neutralizing Shiga toxin 2 (Stx2), was obtained. To prevent a humoral response against murine antibody when used clinically, a humanized antibody was constructed by combining the complementarity-determining regions of VTm1.1 with human framework and constant regions. In addition… (More)

Topics

Cite this paper

@article{Kimura2002DevelopmentOH, title={Development of humanized monoclonal antibody TMA-15 which neutralizes Shiga toxin 2.}, author={Tsuyoshi Kimura and Man Sung Co and Maximiliano V{\'a}squez and Sharon Wei and Hattie Xu and Shinobu Tani and Yuri Sakai and Takashi Kawamura and Yoh-ichi Matsumoto and Hiroshi Nakao and Tae Takeda}, journal={Hybridoma and hybridomics}, year={2002}, volume={21 3}, pages={161-8} }