Development of human liver UDP-glucuronosyltransferases.

  title={Development of human liver UDP-glucuronosyltransferases.},
  author={Brian Burchell and Michael W. H. Coughtrie and Mandy Jackson and D M Harding and Sylvie Fournel-Gigleux and Jonathan Leakey and Robert Hume},
  journal={Developmental pharmacology and therapeutics},
  volume={13 2-4},
The development of multiple UDPGT activities towards eight substrates has been studied in fetal term and adult post-mortem (less than 5 h after death) liver samples. Most fetal and term liver activities were less than 14% of adult values, except that towards 5-hydroxytryptamine which was present in fetal and term liver at adult levels. The majority of UDPGT activities develop to adult levels within 10-20 weeks postnatally, and even premature (30 weeks) which survive for up to 10 weeks will… CONTINUE READING

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