Development of highly sensitive chemiluminescence enzyme immunoassay based on the anti-recombinant H(C) subunit of botulinum neurotoxin type A monoclonal antibodies.

@article{Liu2012DevelopmentOH,
  title={Development of highly sensitive chemiluminescence enzyme immunoassay based on the anti-recombinant H(C) subunit of botulinum neurotoxin type A monoclonal antibodies.},
  author={Zhijia Liu and Chaojun Song and Yongming Li and Fei Liu and Kui Ting Zhang and Yuanjie Sun and Haitao Li and Yuying Wei and Zhuwei Xu and Chunmei Zhang and An-gang Yang and Zhikai Xu and Kun Yang and Boquan Jin},
  journal={Analytica chimica acta},
  year={2012},
  volume={735},
  pages={
          23-30
        }
}
Botulinum neurotoxins (BoNTs) are the most poisonous substances ever known. The early detection of these toxins could bear more time for appropriate medical intervention. The standard method for detecting BoNTs is the mouse bioassay, which is time consuming (up to 4 days) and requires a large number of laboratory animals. The immunologic detection methods could detect the toxins within a day, but most of these methods are less sensitive compared with the mouse bioassay due to the lack of high… CONTINUE READING
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