Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos.

@article{Lincoln2004DevelopmentOH,
  title={Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos.},
  author={Joy Lincoln and Christina M Alfieri and Katherine E. Yutzey},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2004},
  volume={230 2},
  pages={239-50}
}
Abnormalities in valvuloseptal development significantly contribute to congenital heart defects, yet the underlying causes are complex and poorly understood. Early cardiac regulatory genes are differentially expressed during valvuloseptal development, consistent with novel functions during heart chamber formation in chicken and mouse embryos. Distinct valve cell lineages were identified in the leaflets, chordae tendineae, and myotendinous junctions with the papillary muscles based on restricted… CONTINUE READING