Development of head and neck squamous cell carcinoma is associated with altered cytokine responsiveness.

@article{Douglas2004DevelopmentOH,
  title={Development of head and neck squamous cell carcinoma is associated with altered cytokine responsiveness.},
  author={Wade G. Douglas and E. P. Tracy and Dongfeng Tan and Jihnhee Yu and Wesley L. Hicks and Nestor R. Rigual and Thom R. Loree and Yanping Wang and Heinz Baumann},
  journal={Molecular cancer research : MCR},
  year={2004},
  volume={2 10},
  pages={585-93}
}
Growth of head and neck squamous cell carcinoma (HNSCC) is generally associated with an inflammatory component. It is hypothesized that these tumor cells develop mechanisms to evade the growth inhibitory effects of cytokines that are present in the tumor microenvironment. This study determined the changes in responsiveness to inflammatory cytokines that accompany the transition of normal to transformed epithelial cells. Paired primary cultures of normal epithelial cells (NEC) and SCC cells were… CONTINUE READING
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