Development of granulocyte and monocyte adsorptive apheresis in the rat dextran sodium sulfate-induced colitis model.

@article{Tomiyasu2007DevelopmentOG,
  title={Development of granulocyte and monocyte adsorptive apheresis in the rat dextran sodium sulfate-induced colitis model.},
  author={Nobuo Tomiyasu and Keiichi Mitsuyama and Asuka Suzuki and Junya Masuda and Hiroshi Yamasaki and Kotaro Kuwaki and Kosuke Takaki and Shigehiko Kitazaki and Michio Sata},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2007},
  volume={29 4},
  pages={265-8}
}
Granulocytapheresis (GCAP) selectively removes large numbers of granulocytes and monocytes from peripheral blood by adsorptive apheresis, and in patients with ulcerative colitis GCAP has been associated with significant efficacy. However, the mechanism(s) of efficacy of this strategy is poorly understood. This rat model of dextran sodium sulfate (DSS)-induced colitis was to investigate the effect of GCAP on tumor necrosis factor (TNF)-alpha release by peripheral leukocytes. By using mini… CONTINUE READING