Development of glycopeptide-intermediate resistance by Staphylococcus aureus leads to attenuated infectivity in a rat model of endocarditis.

@article{Majcherczyk2008DevelopmentOG,
  title={Development of glycopeptide-intermediate resistance by Staphylococcus aureus leads to attenuated infectivity in a rat model of endocarditis.},
  author={Paul Anthony Majcherczyk and Jean-Luc Barblan and Philippe Moreillon and Jos{\'e} Manuel Entenza},
  journal={Microbial pathogenesis},
  year={2008},
  volume={45 5-6},
  pages={408-14}
}
Glycopeptide-intermediate resistant Staphylococcus aureus (GISA) are characterized by multiple changes in the cell wall and an altered expression of global virulence regulators. We investigated whether GISA are affected in their infectivity in a rat model of experimental endocarditis. The glycopeptide-susceptible, methicillin-resistant S. aureus M1V2 and… CONTINUE READING