Development of gamma-aminobutyric acidergic synapses in cultured hippocampal neurons.

@article{Swanwick2006DevelopmentOG,
  title={Development of gamma-aminobutyric acidergic synapses in cultured hippocampal neurons.},
  author={Catherine Croft Swanwick and N. Rama Murthy and Zakaria Mtchedlishvili and Werner Sieghart and Jaideep Kapur},
  journal={The Journal of comparative neurology},
  year={2006},
  volume={495 5},
  pages={497-510}
}
The formation and maturation of gamma-aminobutyric acid (GABA)-ergic synapses was studied in cultured hippocampal pyramidal neurons by both performing immunocytochemistry for GABAergic markers and recording miniature inhibitory postsynaptic currents (mIPSCs). Nascent GABAergic synapses appeared between 3 and 8 days in vitro (DIV), with GABAA receptor subunit clusters appearing first, followed by GAD-65 puncta, then functional synapses. The number of GABAergic synapses increased from 7 to 14 DIV… CONTINUE READING

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