Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies.

@article{Chan2001DevelopmentOF,
  title={Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies.},
  author={Alexander Chak-Lam Chan and Kwok Wah Chan and John Kwok-cheung Chan and Wing-yan Au and Wai Khoon Ho and Wuey Min Ng},
  journal={Histopathology},
  year={2001},
  volume={38 6},
  pages={510-8}
}
AIMS Hyaline-vascular Castleman's disease (HVCD) and follicular dendritic cell (FDC) sarcoma occurring in the nasopharynx are both extremely rare. We report the first case of transformation of the former into the latter as documented by sequential biopsies. The steps involved in the transformation were described in detail and the possible role of p53 studied. METHODS AND RESULTS The patient presented at the age of 23 years with nasopharyngeal HVCD. Hyaline- vascular Castleman's disease with… CONTINUE READING