Development of focal glomerulosclerosis after unilateral nephrectomy in infant rats

  title={Development of focal glomerulosclerosis after unilateral nephrectomy in infant rats},
  author={Gianni E Celsi and Sven-Olof Bohman and Anita C. Aperia},
  journal={Pediatric Nephrology},
Rats unilaterally nephrectomized in infancy (Nx5) or in adulthood (Nx55) and fed a normal (21%) protein diet were studied at 2, 3 and 6 months after surgery with regard to glomerular filtration rate (GFR) and the development of both albuminuria and focal glomerulosclerosis (FGS) in the remnant kidney. Nx rats were compared with sham-operated animals (S) of corresponding age. The incidence of FGS never exceeded 1.4% in S rats. In Nx5 rats the incidence of FGS was not increased at 2 and 3 months… CONTINUE READING
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