Development of fluridil, a topical suppressor of the androgen receptor in androgenetic alopecia

@article{Seligson2003DevelopmentOF,
  title={Development of fluridil, a topical suppressor of the androgen receptor in androgenetic alopecia},
  author={A. Seligson and B. Campion and J. Brown and Ron C Terry and R. Ku{\vc}erov{\'a} and M. Bienov{\'a} and M. Hajd{\'u}ch and M. Sov{\'a}k},
  journal={Drug Development Research},
  year={2003},
  volume={59}
}
  • A. Seligson, B. Campion, +5 authors M. Sovák
  • Published 2003
  • Chemistry
  • Drug Development Research
  • Nonsteroidal antiandrogens (AA) cannot be topically used for androgenetic alopecia (AGA) because of systemic resorption. A new class of androgen receptor (AR) suppressors designed for safe topical treatment of AGA was synthesized from (3‐amino‐2‐hydroxy‐2‐methyl‐N‐(4‐nitro‐3‐trifluoromethyl)phenyl) propanamide (BP‐34), to contain perfluoroalkyl moieties. The trifluoromethyl derivative (fluridil) at 10 μM decreased expression of the AR in LNCaP human cells by 95%, its serum half‐life was 6 h; it… CONTINUE READING
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