Development of factor VIII antibody in haemophilic monozygotic twins. European Study Group of Factor VIII Antibody.

@article{Frommel1979DevelopmentOF,
  title={Development of factor VIII antibody in haemophilic monozygotic twins. European Study Group of Factor VIII Antibody.},
  author={Dominique Frommel and F. Panicucci and Ugo Baicchi and S. Chiara and Pier Mannuccio Mannucci and Zaverio M. Ruggeri and Jean Yves Muller and Jean Pierre Allain and Janine Seger and Francesco Mercuriali},
  journal={Scandinavian journal of haematology},
  year={1979},
  volume={23 1},
  pages={
          64-8
        }
}
The immunologic consequences of replacement therapy have been studied in 2 pairs of young haemophilic monozygotic twins. In both pairs one cotwin only developed a factor VIII specific antibody. This non-concordance illustrates the influence upon a specific immune response of non-genetic factors since the blood products, administered to each brother-pair, were not at all time identical nor were the regimens of transfusion therapy.