Development of diclofenac sodium-loaded alginate-PVP K 30 microbeads using central composite design

@inproceedings{Nayak2011DevelopmentOD,
  title={Development of diclofenac sodium-loaded alginate-PVP K 30 microbeads using central composite design},
  author={AK. Nayak and Sajal Khatua and MS. Hasnain and KK. Sen},
  booktitle={Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences},
  year={2011}
}
BACKGROUND AND THE PURPOSE OF THE STUDY Diclofenac sodium is a non-steroidal anti-inflammatory agent with a short biological half-life (1-2 hr) and requires multiple dosing. This research was carried out to develop and optimize diclofenac sodium loaded alginate-PVP K 30 microbeads to eliminate the need for multiple dosing and adverse effects. METHODS Diclofenac sodium loaded alginate-PVP K 30 microbeads were prepared by ionotropic gelation. Particle size, drug release, swelling, FTIR and SEM… CONTINUE READING

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