Development of diamidophosphite ligands and their application to the palladium-catalyzed vinyl-substituted trimethylenemethane asymmetric [3 + 2] cycloaddition.

Abstract

A palladium-catalyzed asymmetric [3 + 2] cycloaddition of a vinyl-substituted trimethylenemethane (TMM) donor with α,β-unsaturated acyl imidazoles is described. A newly designed bisdiamidophosphite ligand derived from (S,S)-trans-1,2-cyclohexanediamine and (2R,4R)-pentanediol has been instrumental for the development of this process. This transformation… (More)
DOI: 10.1021/ja305717r

Topics

1 Figure or Table

Cite this paper

@article{Trost2012DevelopmentOD, title={Development of diamidophosphite ligands and their application to the palladium-catalyzed vinyl-substituted trimethylenemethane asymmetric [3 + 2] cycloaddition.}, author={Barry M Trost and Tom M Lam}, journal={Journal of the American Chemical Society}, year={2012}, volume={134 28}, pages={11319-21} }