Development of dendritic cells in culture from human and murine thymic precursor cells.

@article{Kelly2001DevelopmentOD,
  title={Development of dendritic cells in culture from human and murine thymic precursor cells.},
  author={Katherine A Kelly and Karen A Lucas and Hubertus Hochrein and Donald Metcalf and Lin-Wei Wu and Ken D Shortman},
  journal={Cellular and molecular biology},
  year={2001},
  volume={47 1},
  pages={43-54}
}
The earliest T-precursor population in the adult murine thymus can give rise to dendritic cells (DC) in culture if stimulated with a cocktail of cytokines that includes interleukin (IL)-3, but not with cytokine mixes based on granulocyte-macrophage colony stimulating factor (GM-CSF), normally used to generate myeloid-derived DC. This and other evidence led to the proposal that two different lineages of DC exist, one lymphoid-related and the other myeloid-related. To determine whether this… CONTINUE READING