Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression.

@article{Echevarra2007DevelopmentOC,
  title={Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression.},
  author={Miriam Echevarr{\'i}a and Ana M Mu{\~n}oz-Cabello and Roc{\'i}o S{\'a}nchez-Silva and Juan Jos{\'e} Toledo-Aral and Jos{\'e} L{\'o}pez-Barneo},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 41},
  pages={30207-15}
}
O(2) is essential for aerobic life, and the classic view is that it diffuses freely across the plasma membrane. However, measurements of O(2) permeability of lipid bilayers have indicated that it is much lower than previously thought, and therefore, the existence of membrane O(2) channels has been suggested. We hypothesized that, besides its role as a water channel, aquaporin-1 (AQP-1) could also work as an O(2) transporter, because this transmembrane protein appears to be CO(2)-permeable and… CONTINUE READING

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