Development of cytochrome P450 aromatase mRNA levels and enzyme activity in ovaries of normal and hypogonadal (hpg) mice.

Abstract

The cytochrome P450 aromatase (P450arom) enzyme is required for bioconversion of androgen to oestrogen. In this study ovarian P450arom mRNA and enzyme activity have been measured during development in normal mice and hypogondal (hpg) mice which lack circulating gonadotrophins. A semi-quantitative reverse transcription-PCR (RT-PCR) technique was used to… (More)

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