Development of cyclodextrin hydrogels for vaginal delivery of dehydroepiandrosterone.

OBJECTIVE To develop a new vaginal delivery system for a sustained release of dehydroepiandrosterone (DHEA) in the treatment of postmenopausal symptoms, aimed to overcome the problems of poor bioavailability of the drug related to its very low water solubility. METHODS Cyclodextrin (CD)-containing hydrogels were developed, combining in a single device the… CONTINUE READING