Development of conical soluble phosphate glass fibers for directional tissue growth.

@article{Alekseeva2012DevelopmentOC,
  title={Development of conical soluble phosphate glass fibers for directional tissue growth.},
  author={Tijna Alekseeva and Ensanya Ali Abou Neel and Jonathan C Knowles and Robert A. Brown},
  journal={Journal of biomaterials applications},
  year={2012},
  volume={26 6},
  pages={733-44}
}
One of the challenges of tissue engineering is the regulation of vascularization and innervations of the implant by the host. Here, we propose that using soluble phosphate glass (SPG) fibers, incorporated in dense collagen constructs will allow us to control the rate and direction of tissue ingrowth. The idea here was to generate channels with tailored direction using conical phosphate glass fibers. The changing surface area-to-mass ratio of conical fibers will make them to dissolve faster from… CONTINUE READING