Development of concepts of etiology, pathogenesis and treatment of pemphigus vulgaris based on the hypothesis of atavistic origin of the disease.

@article{Grando1991DevelopmentOC,
  title={Development of concepts of etiology, pathogenesis and treatment of pemphigus vulgaris based on the hypothesis of atavistic origin of the disease.},
  author={S A Grando},
  journal={Medical hypotheses},
  year={1991},
  volume={36 1},
  pages={43-52}
}
Atavistically dependent expression of pemphigus vulgaris 'immune' antigen (PVIA) on the human epidermocyte surface is hypothetically the key factor of autoimmune aggression onset in pemphigus patients. Normal epidermocytes can express PVIA in response to a putative factor of 'sheding' as well as to certain biologic, chemical and physical effects. Taking… CONTINUE READING